Uncoupling proteins (UCPs) regulate mitochondrial function, and thus cellular metabolism. Angiotensin‐converting enzyme (ACE) is the central component of endocrine and local tissue renin–angiotensin systems (RAS), which also regulate diverse aspects of whole‐body metabolism and mitochondrial function (partly through altering mitochondrial UCP expression). We show that ACE expression also appears to be regulated by mitochondrial UCPs. In genetic analysis of two unrelated populations (healthy young UK men and Scandinavian diabetic patients) serum ACE (sACE) activity was significantly higher amongst UCP3‐55C (rather than (...) T) and UCP2 I (rather than D) allele carriers. RNA interference against UCP2 in human umbilical vein endothelial cells reduced UCP2 mRNA sixfold (P < 0·01) whilst increasing ACE expression within a physiological range (<1·8‐fold at 48 h; P < 0·01). Our findings suggest novel hypotheses. Firstly, cellular feedback regulation may occur between UCPs and ACE. Secondly, cellular UCP regulation of sACE suggests a novel means of crosstalk between (and mutual regulation of) cellular and endocrine metabolism. This might partly explain the reduced risk of developing diabetes and metabolic syndrome with RAS antagonists and offer insight into the origins of cardiovascular disease in which UCPs and ACE both play a role. (shrink)

The dispute between the empiricist and interpretivist conceptions of the social sciences is properly conceived not as a matter of reduction or covering laws. Features specific to the social sciences include the following. Explanations of human behavior make reference to intentional causation; social phenomena are permeated with mental components and are self-referential; social science explanations have not been as successful as those in natural science because of their concern with intentional causation, because their explanations must be identical with the propositional (...) content of the mind of the actor, and because a social phenomenon exists only if people believe it exists. Elements of an apparatus necessary to analyze this problematic social ontology are given and include selfreferentiality, constitutive rules, collective intentionality, linguistic permeation of the facts, systematic interrelationships among social facts, and primacy of acts over objects. (shrink)

Neuroethics applies cognitive neuroscience for prescribing alterations to conceptions of self and society, and for prescriptively judging the ethical applications of neurotechnologies. Plentiful normative premises are available to ground such prescriptivity, however prescriptive neuroethics may remain fragmented by social conventions, cultural ideologies, and ethical theories. Herein we offer that an objectively principled neuroethics for international relevance requires a new meta-ethics: understanding how morality works, and how humans manage and improve morality, as objectively based on the brain and social sciences. This (...) new meta-ethics will simultaneously equip neuroethics for evaluating and revising older cultural ideologies and ethical theories, and direct neuroethics towards scientifically valid views of encultured humans intelligently managing moralities. Bypassing absolutism, cultural essentialisms, and unrealistic ethical philosophies, neuroethics arrives at a small set of principles about proper human flourishing that are more culturally inclusive and cosmopolitan in spirit. This cosmopolitanism in turn suggests augmentations to traditional medical ethics in the form of four principled guidelines for international consideration: empowerment, non-obsolescence, self-creativity, and citizenship. (shrink)

Is there a distinction between referential and attributive uses of definite descriptions? I think most philosophers who approach Donnellan’s distinction from the point of view of the theory of speech acts, those who see reference as a type of speech act, would say that there is no such distinction and that the cases he presents can be accounted for as instances of the general distinction between speaker meaning and sentence meaning: both alleged uses are referential in the sense that they (...) are cases of referring to objects, the only difference is in the degree to which the speaker makes his intentions fully explicit in his utterance. Such objections are in fact quite commonly made, both in the literature and in the oral tradition, but I have never seen a version of the objection I was fully satisfied with and the main aim of this article is to attempt to provide one. (shrink)

Cognitive Grammar offers a radical alternative to mainstream linguistic theories. This book introduces the theory in clear, non-technical language, relates it to current debates about the nature of linguistic knowledge, and applies it to in-depth analyses of a range of topics in semantics, syntax, morphology, and phonology. Study questions and suggestions for further reading accompany each of the main chapters.

In this paper we shall answer some questions in the set theory of L, the universe of all sets constructible from the reals. In order to do so, we shall assume ADL, the hypothesis that all 2-person games of perfect information on ω whose payoff set is in L are determined. This is by now standard practice. ZFC itself decides few questions in the set theory of L, and for reasons we cannot discuss here, ZFC + ADL yields the most (...) interesting “completion” of the ZFC-theory of L.ADL implies that L satisfies “every wellordered set of reals is countable”, so that the axiom of choice fails in L. Nevertheless, there is a natural inner model of L, namely HODL, which satisfies ZFC.. The superscript “L” indicates, here and below, that the notion in question is to be interpreted in L.) HODL is reasonably close to the full L, in ways we shall make precise in § 1. The most important of the questions we shall answer concern HODL: what is its first order theory, and in particular, does it satisfy GCH?These questions first drew attention in the 70's and early 80's. (shrink)

LAS is a program that acquires augmented transition network (ATN) grammars. It requires as data sentences of the language and semantic network representatives of their meaning. In acquiring the ATN grammars, it induces the word classes of the language, the rules of formation for sentences, and the rules mapping sentences onto meaning. The induced ATN grammar can be used both for sentence generation and sentence comprehension. Critical to the performance of the program are assumptions that it makes about the relation (...) between sentence structure and surface structure (the graph deformation condition), about when word classes may be formed and when ATN networks may be merged, and about the structure of noun phrases. These assumptions seem to be good heuristics which are largely true for natural languages although they would not be true for many nonnatural languages. Provided these assumptions are satisfied LAS seems capable of learning any context‐free language. (shrink)

Multi-voxel pattern recognition techniques combined with Hidden Markov models can be used to discover the mental states that people go through in performing a task. The combined method identifies both the mental states and how their durations vary with experimental conditions. We apply this method to a task where participants solve novel mathematical problems. We identify four states in the solution of these problems: Encoding, Planning, Solving, and Respond. The method allows us to interpret what participants are doing on individual (...) problem-solving trials. The duration of the planning state varies on a trial-to-trial basis with novelty of the problem. The duration of solution stage similarly varies with the amount of computation needed to produce a solution once a plan is devised. The response stage similarly varies with the complexity of the answer produced. In addition, we identified a number of effects that ran counter to a prior model of the task. Thus, we were able to decompose the overall problem-solving time into estimates of its components and in way that serves to guide theory. (shrink)

This work is intended as an introduction to the study of Soviet psy chology. In it we have tried to present the main lines of Soviet psycho logical theory, in particular, the philosophical principles on which that theory is founded. There are surprisingly few books in English on Soviet psychology, or, indeed, in any Western European language. The works that exist usually take the form of symposia or are collections of articles translated from Soviet periodicals. The most important of these (...) are Psychology in the Soviet Union (ed. by Brian Simon), Recent Soviet Psychology (ed. by Neil O'Connor) and Soviet Psychology, A Symposium (ed. by Ralf Winn). Raymond Bauer has also edited an interesting symposium entitled Some Views on Soviet Psychology. Only two systematic studies of Soviet psychology have been published to date: Joseph Wortis' Soviet Psychiatry and Raymond Bauer's The New Man in Soviet Psychology. Both are valuable introductions to Soviet psychology; Bauer's book, in particular, gives a good account of the debates on psychological theory in the Soviet Union in the nineteen twenties and -thirties. Both, however, are somewhat out of date. There are also a number of interesting articles written by Ivan D. London and Gregory Razran, which give general surveys of particular periods or aspects of Soviet psychology. These have been listed in the bibliography. (shrink)

The present article presents Wang Fuzhi 王夫之 (1619-1692 C.E.)’s reading of the eighteenth chapter of the Zhuang-Zi 莊子 (ZZ) by looking at his entry from Zhuang-Zi-Tong 莊子通 and other key glosses from Zhuang-Zi-Jie 莊子解. The philosophical upshot, I aim to show, is that Wang takes ZZ as presenting the consummation of “the greatest joyousness” (zhi-le 至樂) as requiring getting rid of joyousness as one’s desideratum. Using Derek Parfit’s work as a point of reference, I aim to show that this is (...) not paradoxical or even inconsistent or even (directly or indirectly) self-defeating but is instead an interesting instance of a self-effacing theory. (shrink)

This chapter contains sections titled: Schiller's Humanism, Personalism, and Pragmatism Pragmatism and France Pragmatism in Italy Germany and Pragmatism Other European Philosophers and Pragmatism.

A study of some London newspapers of the early 1770s has shown that Martin and Ferguson gave continuous courses of evening lectures during the winter, in direct competition with each other. In this paper the coverage of their courses is derived from their advertisements, and related to their publications and other activities. In some subjects, such as Electricity, Hydrostatics, and Air-pump Experiments, there was close correspondence between the courses, but others reflected the lecturers' primary interests: for Martin, Optics, and for (...) Ferguson, Mechanics and Astronomy. (shrink)

Today’s international business environment is complicated by human rights abuses and social and economic repression in variouscountries. This paper introduces controversies with foreign investment in Burma to develop and describe alternative terms of global business engagement in ethically challenging settings. Two forms of engagement—unrestricted and constructive—and two forms of non-engagement—principled and sanctioned—are discussed. All four alternatives are examined for their ethical, social change, andcultural foundations. Additional considerations are posed in respect to constructive engagement, moral leadership by global businessexecutives, needs for (...) model building and evaluative research, and realities in the ethical context of global business. (shrink)

Pragmatism, the philosophy native to America, has once again grown to prominence in philosophical debate around the world. Today, the type of pragmatism that is proving to be of greatest value for fostering discussions with other worldviews is pragmatic naturalism. The fourteen provocative essays in this original collection are all by philosophers who describe themselves as pragmatic naturalists and who are active in the present-day revival of American pragmatism. Pragmatic naturalism, like all varieties of pragmatism, steers clear of the extreme (...) intellectualism too often found in philosophy. Pragmatic naturalism stresses that genuine inquiry must be conducted in a consistently empirical manner and be responsive to real human problems. It also contends that the sciences and their methodologies are superior to other modes of inquiry into the human environment. Despite the curious fact that pragmatism is often taken to be opposed to realism, the essays in this volume assert the interdependence of pragmatism with some type of realistic metaphysical stance. As such they advance the debates over the question of realism by uncovering and investigating the deepest assumptions running through recent Anglo-American philosophy. This excellent collection of high-quality essays on a resurgent school of American philosophy will be of interest to philosophers as well as scholars in the natural and social sciences. (shrink)

How should ethics help decide the morality of enhancing morality? The idea of morally enhancing the human brain quickly emerged when the promise of cognitive enhancement in general began to seem realizable. However, on reflection, achieving moral enhancement must be limited by the practical challenges to any sort of cognitive modification, along with obstacles particular to morality’s bases in social cognition. The objectivity offered by the brain sciences cannot ensure the technological achievement of moral bioenhancement for humanity-wide application. Additionally, any (...) limited moral enhancement will not easily fulfil ethical expectations. Three hypothetical scenarios involving putative moral enhancement help illustrate why. Philosophical concerns about the “Does-Must Dichotomy” and the “Factor-Cause Plurality,” as I label them, forbid easy leaps from views about morality on to conclusions about ways to enhance morality, and then further on to ethically justifying those enhancements. A modest and realistic approach to moral enhancement emerges from exploring these issues. (shrink)

In the 1990s, the role of the chief executive officer (CEO) of major United States corporations underwent a profound transformation in which CEOs went from being bureaucrats or technocrats to shareholder partisans who acted more like proprietors or entrepreneurs. This transformation occurred in response to changes in the competitive environment of U.S. corporations and also to the agency theory argument that high levels of compensation by means of stock options helped to overcome the agency problem inherent in the separation of (...) ownership and control. Some critics charge that this new CEO role is objectionable for a variety of reasons, which may also be applicable to the current financial crisis in which CEO misconduct may have played a part. These objections are based largelyon a team production model of corporate governance, which is held by these critics to be superior to the standard agent-principal model. This article examines the objections offered by critics of the changed role of the CEO and argues that their negative assessment of this development and their use of the team production model to support their conclusions are not warranted. CEOs have changed from hired hands to co-owners, and this change may have contributed in some measure to the current financial crisis. However, in determining the morally preferable role of the CEO, care must be taken not to discard what is sound in the changed role. (shrink)

Rent seeking by lobbying for government favors is generally thought to be wasteful. In view of this wastefulness, it is puzzling that rent seeking by corporations has not been criticized as a failure to be socially responsible or even as an unethical business practice. This article examines the compatibility of rent seeking with corporate social responsibility by utilizing Thomas Dunfee's idea of a marketplace with morality. This idea is useful for solving this puzzle because in considering whether rent seeking is (...) compatible with corporate social responsibility, it is necessary, first, to define rent seeking, which this article argues is a normative concept, and, second, to find some principled way of identifying rent-seeking behavior. It also solves the puzzle about rent seeking by revealing that the concept of rent seeking itself is of little use in determining whether certain conduct is or is not socially responsible since rent seeking activity cannot be identified without first evaluating which activity is rent seeking. (shrink)

This volume recreates the received notion of reflective equilibrium. It reconfigures reflective equilibrium as both a cognitive ideal and a method for approximating this ideal. The ideal of reflective equilibrium is restructured using the concept of discursive strata, which are formed by sentences and differentiated by function. Sentences that perform the same kind of linguistic function constitute a stratum. The book shows how moral discourse can be analyzed into phenomenal, instrumental, and teleological strata, and the ideal of reflective equilibrium reworked (...) in these terms. In addition, the work strengthens the method of reflective equilibrium by harnessing the resources of decision theory and inductive logic. It launches a comparative version of decision theory and employs this framework as a guide to moral theory choice. It also recruits quantitative inductive logic to inform a standard of inductive cogency. When used in tandem with comparative decision theory, this standard can aid in the effort to turn the undesirable condition of reflective disequilibrium into reflective equilibrium. (shrink)

To promote so-called cultural competence in work of direct-care providers and other health professionals among diverse peoples, cross-cultural training is now widely advised. However, in ethically assessing aims and content of CCT, and surrounding issues and concerns, what should guide us? And if we can elaborate satisfactory moral touchstones, what do they imply for healthcare professionals, overarching structures, and bioethicists? Building on prior work, this paper tries to help answer these questions.

The focus of this study is cognitive choice: the selection of one cognitive option (a hypothesis, a theory, or an axiom, for instance) rather than another. The study proposes that cognitive choice should be based on the plausibilities of states posited by rival cognitive options and the utilities of these options' information outcomes. The proposal introduces a form of decision theory that is novel because comparative; it permits many choices among cognitive options to be based on merely comparative plausibilities and (...) utilities. This form of decision theory intersects with recommendations by advocates of decision theory for cognitive choice, on the one hand, and defenders of comparative evaluation of scientific hypotheses and theories, on the other. But it differs from prior decision-theoretic proposals because it requires no more than minimal precision in specifying plausibilities and utilities. And it differs from comparative proposals because none has shown how comparative evaluations can be carried out within a decision-theoretic framework. (shrink)

Mental images are one of the more obvious aspects of human conscious experience. Familiar idioms such as “the mind's eye” reflect the high status of the image in metacognition. Theoretically, a defining characteristic of mental images is that they can be analog representations. But this has led to an enduring puzzle in cognitive psychology: How do “mental pictures” fit into a general theory of cognition? Three empirical problems have constituted this puzzle: The incidence of mental images has been unpredictable, innumerable (...) ordinary concepts cannot be depicted, and images typically do not resemble things well. I argue in this paper that theorists have begun to address these problems successfully. I argue further that the critical theoretical framework involves thinking of mental images as information within a cognitive system that is fundamentally adaptive. The main outline of the adaptationist framework was evident in the school of thought known as American Functionalism, but adaptationism has formed a consistent pattern of theorizing across many authors and decades. I briefly describe Functionalism and then present seven basic claims about imagery that were common in the years before the predominance of behaviorism. I then show how these claims have reappeared and been further articulated in modern cognitive psychology. I end with a brief integration of some of the basic elements of an adaptationist theory of imagery. (shrink)

Although enterprise risk management (ERM) has many benefits for corporations, there has been virtually no discussion of the extent to which its practice may be said to constitute corporate social responsibility. This article presents a prima facie case for the convergence of the two and examines this case through a consideration of four possible objections or challenges. The conclusion of this article is a tempered optimism that ERM has the significant, but as yet untapped, potential to constitute socially responsible activity, (...) which, if realized, would enable Adam Smith's invisible hand of the marketplace to have an expanded sweep. (shrink)

This paper revisits the Pinto case not merely for the purpose of demythologizing the case, but as an opportunity to examine the broader issue of the logic of blame, the ascription of legal and moral responsibility. Three issues are addressed in the contexts of fault and liability in tort, criminal liability and product liability: 1) To what extent can judgments of moral wrongdoing or blame be inferred from legal judgments? 2) What are the strengths and weaknesses of attempting to model (...) moral arguments upon legal ones? and, 3) What is the nature and role of judgments of risk evaluation in legal and moral judgments? (shrink)

Atheology, accurately defined by Alvin Plantinga, offers reasons why god’s existence is implausible. Skeptically reasoning that theological arguments for god fail to make their case is one way of leaving supernaturalism in an implausible condition. This ‘rationalist’ atheology appeals to logical standards to point out fallacies and other sorts of inferential gaps. Beyond that methodological marker, few shared tactics characterize atheists and agnostics stalking theological targets. If unbelief be grounded on reason, let atheology start from a theological stronghold: the principle (...) of sufficient reason, a cornerstone of rationality. Seven rules, corollaries to that principle, are enough to show how theological arguments for god repeatedly contravene rationality by perpetuating mysteries, contradictions, begging of questions, pseudo-explanations, and the like. None of these complaints are new, nor has theology been unaware of them. Disorganized atheology has, so far, allowed theology to appear to answer them. Five major arguments for god are systematically analyzed and refuted using these seven rules of rationality, as a preliminary exercise illustrating this re-organized and re-focused rationalist atheology. (shrink)

This chapter explores arguments from analogy containing ethical predicates like 'just', 'courageous', and 'honest'. The approach is Wittgensteinian in a double sense. The role of paradigm cases in ethical discourse is emphasized, first of all, and the inductive logics to be employed spring from Wittgenstein's remarks on probability (1922). Although these logics rely on a semantic concept of range, they yield results for the ethical problems treated here only if grounded in certain kinds of pragmatic consensus.

One way to recast the problem of cultural explanation in historical inquiry is to distinguish two conceptualizations involving culture: cultural meanings as contents of signification that inform meaningful courses of action in historically unfolding circumstances; and cultural structures as institutionalized patterns of social life that may be elaborated in more than one concrete construction of meaning. This distinction helps to suggest how explanation can operate in accounting for cultural processes of meaning-formation, as well as in other ways that transcend specific (...) meanings, yet are nonetheless cultural. Examples of historical explanation involving each construct are offered, and their potential examined. (shrink)

A survey of Kant's philosophical writings reveals an ongoing concern with the problem of moral motivation. The problem is expressed thusly: How can a judgment of the understanding provide a motive sufficient to move the will to an action? ;Kant provides one line of argument in his formal writings on moral theory. The feeling of respect that follows from the recognition of the nobility of the universal moral law provides the motivation or incentive. Through this feeling we are aware that (...) we are beings that belong to an intelligible world that is independent of the mechanism of the sensible world. We are made aware of a higher, supersensible vocation and thus the sublimity of our own nature. ;There is another line of argument, however. A survey of Kant's philosophical writings also reveals a connection between the moral and the aesthetic. In the second Critique duty is called sublime; in his lectures on Ethics from the mid-1760's the feeling that results from free moral action is described as beautiful or sublime. In the Observations on the Feeling of the Beautiful and the Sublime the sublime is described as a "finer" feeling that moves us as we see the dignity of our own nature displayed in presentations of virtue. In the Critique of Judgment the feeling of the sublime is an experience that makes us aware of our supersensible vocation. Awareness of our supersensible nature through the feeling of pleasure and displeasure provides additional moral motivation and supports the incentive provided by the cognitive faculty's formulation of the moral law. ;A survey of Kant's philosophical writings and especially the unpublished lectures on Ethics, Logic and Metaphysics reveals a continuity in Kant's thought in terms of the relation between the moral and the aesthetic and in terms of concern with the problem of moral motivation. The third Critique was intended as the "keystone of the critical arch," but Kant apparently was not satisfied. The Opus postumum reveals the unity Kant was seeking: the supersensible and the sensible are united in the human person through the feeling of pleasure and displeasure. (shrink)